Try:
1. Repair IE from Config Panel/Add Remove Software.
2. Run all five programs from Bob's Anti-Parasite Suite: http://reviews.cnet.com/5208-6132-0.html?forumID=32&threadID=1313&start=0. CWShredder has moved, find it's new location with Google.
3. Download Mozilla (or Mozilla Firebird) from www.mozilla.org to see if another browser works, so we're sure it is an IE problem.
Kees
When I am at a web site explorer freezes up and have to use ctrl-alt-del to get out and start all over.
This happens all the time. Explorer 6.0

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic