I believe the last update to EasyCleaner was nearly two years ago, well prior to Vista's launch, so it was not designed or updated to be compatible. However, it's still frequently recommended for Vista users as most issues reported are relatively minor.
I have been doing a C/NET course that recommended EasyCleaner in lesson 3. The trouble is from my understanding of this lesson EasyCleaner is Vista compatable but when I follow the link there is no mention of Vista and when I run the the program it works in some ways but when I try to find all the Duplicate programs on my Hard Drive the program starts and the terminates. Is it Really Vista compatable? even the interface is not 100% right, It has to Radio buttons for the minimize option (weird).