E Machines - Not finding the hard drive

I repair computers for senior citizens - no charge - but I get a lot of home-made sweets!
Once in a while someone donates a unit - I get it running and pass it on to someone in need.
I have an E Machines T3882, running XP. I got it thru a 3rd party so I cannot contact the orginal owner. I was told the unit had a "virus". Rather then check for myself (an error) I turned it on, loaded Malwarebytes from CD and ran a full scan. Somewhere during the process, it hung up and I found the hour glass and nothing happening. I powered down and rebooted - it never booted up again. I get the big "E" logo - and several minutes later a message saying no hard drive was found.
Any ideas?

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Did you try the usual?

New cable or drive?

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E Machines - Not finding the hard drive

I re-seated all the power connections and the ribbon connections. I wondered whether running the Malwarebytes triggered something. As I mentioned I know none of the history - only that the previous owner replaced it due to a "virus". I have heard a lot about E Machines power supplies being suspect - but would the logo screen come on if the power supply was bad?

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HDDs do fail.

And on the rare occasion I've had IDE ports fail. So I swap the cable then HDD and hope it's never the IDE port.

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