If you don't have much RAM, so make extensive use of virtual memory, it might have effect on the hard disk or SSD, not on the RAM or motherboard.
Does it impact my hardware in the long term "ram ..motherboard ..etc ??.. I'm ok with my pc performance while in these programs ..what i just wanna what happens to the hardware after months or years ..

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic