Ann D, Which version of Windows are you using?
Note: If you're asking for technical help, please be sure to include all your system info, including operating system, model number, and any other specifics related to the problem.
As far as a registry cleaner if you're not familiar with the registry stay away from them as they can do more harm than good.
Which programs when you try to run them cause the error message?
You can easily create new shortcuts.
There are many hits on this problem at the link below.
Lately I am facing some very weird RunDLL32 errors while I am trying to run programs I need for work. Also some shortcuts are blank, and no longer point to correct application.
Here is image of screenshot I took: http://img718.imageshack.us/img718/3414/rundll.png
Some of my so-called tech friends have recommended me to install good antivirus with built-in firewall, which I already have (Kaspersky 2010) and get some good registry cleaner software.
Since I am a tech newbie, I've been checking many reviews like http://fixexe.com/best-5-registry-fix-and-repair-tools/ and most of them seem to recommend Registry Easy, or ACA Utilities.
I hope you guys can advise me what registry cleaner to choose, if choose at all?
Any help would be more than welcome!