I ever connected my Android to my PC was to charge it. There's really no need to connect it to a PC/MAC directly, because everything can be synchronized online (emails, files, contacts, call history, pictures) and most of those applications work entirely from a Web browser, so that's pretty platform independent.
The only downfall may be iTunes content, but a quick search online shows that people have synced their iTunes with their Android on a MAC.
So here's the conundrum. I'm looking to buy a new smartphone and the Androids are really tempting me as compared to the Iphone. GIven the fact that I have a Macbook though, would it be wise to go for an Android? The iphone and Mac just go together (duh). Anyone out there who can vouch for the Androids working seamlessly with the Macs (in terms of syncing and stuff)?