There are a few things you can do. Hit control alt delete and end task to all items except for explorer and systray. Also go into your control panel and turn off your active desktop, which is turned on when you have certain wallpapers present. Also you may want to try standard scan disk after doing the suggestions above before defrag.
This should allow you to run defrag
I am needing help using my Disk Defragmentor. It used to work but now it doesn't. It just keeps starting over and over and it never get past 1%. I have Windows ME. I have had my computer about 3 years but still don't know very much. I don't have any other programs running at the time I try to defragment but something must be writing to it thats why it doesn't work but for the life of me I don't know what it could be. My computer is a Dell Dimension 2100.