Call the maker of the program and ask for the solution.
Only the generic answer is offered since your post doesn't tell much about the software maker, title, version and more.
Bob
I am using windows home premium and just purchased this computer. A program i installed wont run and it shows disabled how do i fix this
thanks for any help

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic