I don't think XP will let you do this and have not seen third party utilites that will either. You might be able to delete a lot of stuff MS updates leave on the drive such as are found in the Windows folder. These tend to have identifying names. Another alternative would be to use a second drive as storage. You can move the My Documents folder for each user to the other drive and keep the primary drive a lot cleaner. Hope that helps.
I have XP, and I want to free up some HD space and speed up my Virus scans. I delete a lot of files in my Local Settings folder for my account such as Temporary, Temporary Internet Files, History, etc. Anyway, as far as I know, these are safe to delete. Anyway, there are many users on this computer and it's annoying to have to go into each folder for each user to delete everything. Is there any easy way to delete all these files in say one easy click.