Try following the procedures in ALL of the links below. Use the links in the order that I give them.
How To Shut Down Unnecessary Start Up Programs
How To Clean Unwanted Files From The Hard Drive
What Do I Do When Scandisk and Defrag Won't Run In Win9.x/ME
Hope this helps.
Grif
I freely admit to being Computer Stupid..I need help please??? I have Windows ME and for whatever reason my defragmenter will no longer defragment. I am clueless. would be greatful for any reply. Please us small words and please do not use a lot of computer speak. Thank You

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic