It very much depends on how you use the computer. If you do a lot of Internet surfing you may want to run Disk cleanup occasionally. I run it about every two weeks or so. Usually when my Temporary Internet files folder gets
about 60-70% full. I set my Temporary Internet files folder size to 100MB. Start > Control Panel > Internet Options > General tab > under Temporary Internet files click on Settings > set the Amount of disk space to use > OK > OK. While you're there it may be a good idea to select the radio button beside "Automatically.
A good way to judge when the Temporary Internet files folder is getting too full is that web Page loading will begin to slow down. These Temporary Internet files are cashed web pages and images of web pages that are used to speed up the loading of web pages that were previously visited. But the more files that are saved, the more searching must be performed before the page loads. On the other hand, when the files are cleared/deleted these pages must again be searched out by the ISP and completely downloaded.
While you are at Start > Control Panel > Internet Options > General tab, under History it is a good idea to set the number of days at three or less.
Also, at Start > Control Panel > Internet Options > General tab I would suggest using your best judgement when deleting Cookies. As some of these Cookies save login information such as here at the CNET Forums so you don't have to login every time you return. Also, many banking and shopping sites place special Cookies on the machine so they can recognize your computer so you only need to enter a password, and avoid having to answer special security questions.
When you run Disk cleanup I recommend placing a check mark beside each item in the list except "Compress old files". Compressing files, even just old files can greatly slow down the computers ability to access and close files. It only results in a big waste of time and overworks the Hard drive. That is, unless you are hard-up for memory space. In which case it's probably time to buy an additional or larger Hard drive.
As for Defragging. Unless you do a lot of installing and uninstalling of programs and play a lot of video games, at two or three months is probably plenty.
Sorry to get so long-winded. Hope you find something useful in this.
I have a Gateway GT5220 with a 250 GB Hard Drive and i was just wondering how often i should run disk cleanup, ccleaner, and the disk defragger.
Any help will be appreciated!