It is much like comparing a Chevrolet Impala to a Buick LaCross.
They are more alike than different.
Both get you were you are going.

Nikon D60 and D80.
If you put the same type of lens on both cameras, they will produce identical pictures.
The D80 has more features.

Here is a comparison of specifications:

Notice the green links right under the photo of the camera.
Click that link for a complete review of the camera.