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Could this finally provide hope for HIV/AIDS?

by TONI H / May 17, 2009 4:34 AM PDT
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Looks very promising doesn't it.
by MarkFlax Forum moderator / May 17, 2009 4:44 AM PDT

Hopefully this will be a major step forward.

I'm not sure whether that article is saying this is a possible 'cure' for HIV, or immunization against being infected with it.

"A month after administering the AAV, the nine treated monkeys were injected with SIV, as were six not treated in advance"

It seems they immunized the 9 test monkeys first, then infected them with SIV, the simian form of HIV. So from that at these early stages it looks like immunization only.


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Immunization "only" is
by TONI H / May 17, 2009 5:12 AM PDT

a glass half full to me.....if we can be immunized against polio and wipe it out, this looks more than promising in my opinion for stopping this devastating disease cold. It may not be much help for people already infected, but it's a great beginning for hope on the horizon.


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(NT) True.
by MarkFlax Forum moderator / May 17, 2009 5:26 AM PDT
In reply to: Immunization "only" is
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I imagine it would still be a long time before
by Steven Haninger / May 17, 2009 8:33 AM PDT
In reply to: Immunization "only" is

such a vaccine had proven itself enough to be considered as part of the childhood regimen such as MMR, polio and TB are today. Even these don't always go well. Of course it may sure well be the insurance companies that will influence whether or not there can be wide spread use of such a vaccine....unless government considers picking up the tab in an effort to eradicate rather than manage the disease.

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Government already picks up the tab for a lot of vaccines
by Bill Osler / May 17, 2009 9:10 AM PDT

The details vary by state, but in North Carolina most childhood immunizations are already paid for by either state or federal government.

I would hope that it will be MANY years before a new vaccine like this becomes a routine part of the childhood immunization schedule. We need to be EXTREMELY cautious about adopting vaccines based on novel technology. If something went wrong it would just add fuel to all of the existing anti-vaccination junk that is already floating around.

OTOH, if the initial trials look good then making the vaccine available for older patients who request it may take just a few years.

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That is interesting ...
by Bill Osler / May 17, 2009 6:05 AM PDT

Assuming that the technique can be safely used it has potential to be very effective as a preventive measure. As someone already observed the vaccine they are currently working with does not offer a cure but the ability to prevent HIV would be HUGE.

I'm a bit concerned about using genetic therapy to prevent infection because that means the vaccine presumably bypasses some of the steps that regulate the immune system. My guess is that creates considerable potential for adverse effects down the road. Still, for high risk patients (and the majority of the people who get HIV do have known high risk) even an imperfect vaccine might be worthwhile. The other situation in which it might be worthwhile if the vaccine works fast enough would be as a post-exposure preventive measure to be used after known accidental exposure.

Of course the vaccine may well work better than I'm predicting, which would be wonderful.

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(NT) Great news!
by lylesg / May 17, 2009 10:44 PM PDT
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