Which operating system? How much RAM?

For most such questions, I suggest following general cleanup procedures using the link below.. Use the first link to eliminate the possibility of the "PIO Only" problem.. Next, use the second link to Clean out malware.. Eliminate unnecessary startup programs and services.. Clean out the junk files, etc.

Tried The DMA Toggle?

Cleanup Steps

Hope this helps and let us know how it goes.

Grif