Sorry to ask, but are you sure it's safe mode? It too often happens that it's just normal mode with the screen resolution set to abnormally low values. Then simply restore it to what you want.
Safe mode is only safe mode if the text 'Safe Mode' appears in the corners of the desktop.
I am running Windows 98 and something happened where the computer only boots up in safe mode. I have reloaded the operating system but that doesn't help. Any suggestions on how to fix this?