You should be able to remove the back cover from the set. You may have to remove screws around the connection area too, as this will be connected to some sort of board inside. I would certainly caution you about power issues, make sure the set is unplugged. Once removed,in most big screens you will now be exposed to a mirror,(the mirror will often be attached to the back cover you removed) and you will see the 3 "guns" red/blue and green. If you are unsure of what to use to clean, go to any quality camera store, find out what they would recommend to clean expensive camera lenses with, this should be safe for the mirror and lenses inside the TV. Obviously you do not want to use anything that could be abrasive. Some sets, like Pioneer, you will want to enter from the front, by removing the screen, this will give you a chance to clean that too. For someone that is comfortable with what they are doing this should take about 1 hour. Good luck.