Is the DVD drive a IDE (flat wide data cable attached to back) or SATA type interface?
If its SATA and the HD is SATA try swapping the data connections at the board or at the devices and try booting.
If its IDE, inspect it carefully; make sure it didn't come into contact with any hot spots inside the case and partially melt or get damaged in any other way. Pull it off both ends and reseat again.
You'll get a better idea of where the clicking is coming from with the cover open as well (needless to say, don't touch anything while its plugged in or running, and touch the computer frame to equalize any electrical charges before touching the more sensitive internals). If its the hard drive it probably needs to be replaced. That will give you the disk read error but a mis-set BIOS (setup) will also give that error. If the optical drive is clicking replace that.
None of the feedback you've provided so far would indicate you are getting any boot response from the DVD drive. If you can try another known good boot disc, for anything else, doesn't matter what because you just want to know if it will boot from the optical drive (a LINUX Live CD or a virus cleanup CD perhaps). If nothing boots, then it has to be a bad drive or misconfiguration in the setup (or bad cable mentioned earlier).
Once you get it up and running again (easier said...) and set up as you like it, a better methodology than what Man from Mars does, is to image the entire drive with something like EaseUS TODO backup and save that for easy recovery to a pristine state in a fraction of the time. I install about 125 gigs of games so its mandatory I image my system because recovery would take up to 2 weeks for me (fairly slow Internet connection for downloading Gamespot and Steam platform games).