Those are the uninstallers associated with every Windows security and stability patch you've downloaded. After you download a hotfix, wait a few days to make sure no problems come up...if none do, it's safe to remove the hotfix uninstallers to save space. Note that that will not uninstall the hotfixes (patches/updates). 128MB is a lot of space, so I'd go ahead and remove them, provided the updates haven't caused you fits.
Hope this helps,
John
In cc>windows>advanced>hotfix uninstallers it shows 185mb being used. What are they? can these be removed w/o backup or creating a restore point?

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic