Is this the second install you are trying to activate? Many softwares only allow install, activation on one machine.
I recently purchased and installed Trend Micro Internet Security 2008 on a secondary desktop PC and updated everything.
While it will scan, I cannot "activate the subscription". It keeps telling me that I must reconnect to the internet in order to activate but I AM connected to the internet and CAN open web pages.
Trend Micro support page doesn't help.