The TomTom XL 330S would be your best bet. 4.3" widescreen, text to speech, and an easy interface to navigate. You can find them close too $200 on sale online.
I'm in the process of buying a in car GPS system for my aging parents, who need a decent sized screen (4.3"), loud speaker, and easy usability. Feature set doesn't need to be great, buy text-to-speech would be nice. I'm looking to spend $100-250.
So far I am looking at the Tomtom ONE XL or the Garmin Nuvi 200w.
Which would be a better suit for my parents? Or are there better options out there?
Thanks

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic