Close Safari,
Double click the hard drive icon on the desktop.
In the sidebar, on the left, where you see Desktop, applications, documents, etc.
Click on the little house. The one with your name on it
In the next window, find the Library. It may be easier to find it if you are using List View. On the icons in the bar across the top of the window, there are 4 together. Left to right, four little squares, four horizontal lines, a window with three panes(kinda) and a black square with 2 lines on each end.
Click the 4 horizontal lines. (List View)
Find Library and click on the triangle shape to the left of it. This expands it
Find Preferences in the list. If it is not a list, repeat the previous step with the 4 lines
Click the triangle shape, make the view a list
Find com.apple.Safari.plist
Click on it ONCE.
Hold down the Control Key and click on it ONCE more.
In the resulting Menu, choose, Move to Trash. Click it.
It is now deleted. The Control key is the same as a right click on a two button mouse and as I don't know what computer you have, we went the long way. If you have an iMac, is probably came with a Mighty Mouse which looks like a one button mouse but is actually a 5 button, or more, mouse.
Launch Safari and see what happens.
Next step is to Reset Safari but this first one may work for you
Let me know how you go on. There are more things to try.
P
I am using Mac 10.4.11 and Safari 4. After adding updates to the computer and restarting, when I opened Safari, web pages were blank or had material only on the far right-hand side of the screen. In addition, the pages were far too wide and no scroll bar could be seen. Someone suggested that I delete "com.apple.safari.plist". When I searched for this, 3 items were listed, one from today, one from 3/09 and one from 2006. I did not see any option to delete. Any suggestions would be welcome. I am currently using firefox and having no problems there.
Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic