There is no single best "all around" program, but what you currently have, Ad-Aware and Spybot are the most recommended here.
In addition, for something more proactive, you may also want to try SpywareBlaster from: http://www.javacoolsoftware.com/spywareblaster.html This is similar to the Immunize feature of Spybot, but offers much more extensive protection.
Another program offering real-time protection against spyware, much the same as your Anti-virus protects against viruses is SpywareGuard. http://www.javacoolsoftware.com/spywareguard.html
Hope this helps.
I wanted to know what the best "all around" software for removing spyware software, preventing pop-up ads... any other function worthwhile . I have reviewed alot of critics comments and getting a little overwhelmed. I run Lavasoft Adare, and Spybot but I wanted something more proactive.