You said, ''Just need to make sure I get this right. If I download a program or file and norton 2005 detects it and automatically removes it, It is now safe to run the program and or open the file correct''
So, if you download a program or file and Norton detects a virus it deletes it. In that case, what is there for you to open? The file has been deleted.
If a program file or any other sort of file has a virus infection it is quite likely that Norton will delete the whole file. You may have the option to ask Norton to repair the file, but that very often does not work.
You will need to find another source for that program or file, and if you are using P2P for downloading, then you should beware that anything you download may be infected. Commercially purchased programs would not, of course, be infected.