You can safely delete the infected file. Then run SFC /Scannow with your Windows cd in the cd drive. This will replace any missing files in windows.
I'm having a bit of difficulty getting rid of this virus! The file that is infected is the "appmgr.dll" file which can be found in my system32 folder. From what I've found on the Trend-micro PC-cillin website, it has info on a TROJ_FAKEVIR.D virus...mine is .F... Anyway, the .D one infects .dll files as well and the solution that the website lists is to simply go into safe mode and delete the file. Well I already tried that and figured it wouldn't work since the appmgr.dll file is a critical file for whatever computer processing... My virus programs are unable to "clean" the file so I'm wondering what to do...
The virus is actually fairly passive...it's not causing any problems as far as I can tell like spamming popups or slowing down my computer...however occasionally it does display a small popup at the bottom of my screen saying that my computer is infected and I need to go download a program that can clean it...etc... Please help though! Thanks!