with the USB hub that is inside the keyboard.
What result do you get if you plug the mouse directly into the powered hub?
I have a mini, about 4 years of age, since the update to 10.6.4 when the mouse is attached to the keyboard it is nor recognised on startup unless I unplug it and plug it in again, when it springs to life. It is not an apple mouse, just a cheapo boa usb mouse. The keyboard (aluminium, same age as mini) is plugged into a powered usb hub. I have played around a bit and even when the keyboard is plugged directly into the mini the mouse is not seen at first. However, when the mouse is plugged directly into the mini there are no problems.
I have swapped the mouse with a variety of other mice including one from an ancient imac, it makes no difference.
Is this a symptom of possible keyboard failure to come, or something else?