Fireant; The 'wheel wobble' is my concern. Could very easily be a wheel bearing. Without seeing it, I would recommend that you have the truck towed, just to be safe. The grinding noise could also be a bearing issue or just some gravel that got stuck in the brake area. Whether or not you have towing insurance, that would be the way to go. JMHO
Loren
I have a 92 GMC Sierra 2500 with 4wd. I was driving about 60 miles round trip on the freeway (a weekly trip in this vehicle) and during the last 5 miles I started hearing a high pitched screeching-grinding combo from the driver's side front wheel. It would happen whenever I went over a slight bump. I slowed down to 20mph and noticed the wheel was wobbling.
Made it home and inspected the outside. I'm not very auto savvy so nothing looked out of place to me. Two days before, I had thrown it into 4wd to get up a gravel hill but took it out after. I haven't driven it since (been a couple weeks) and really just want to know if I'll be safe driving it 5 miles to the nearest shop without the wheel coming off.
For the record, it's about 160k miles. I've had it for two years with no problems, three months of that time it had an over-cab camper on the back that was within the load limit. It's about due for a tire rotation. It's an automatic and has great tread still so balding isn't an issue. Thanks

Chowhound
Comic Vine
GameFAQs
GameSpot
Giant Bomb
TechRepublic