It makes a difference as does one's location. Some variables are the browser (and it's setup), AV/Malware programs, Ad blockers, different ISPs and their firewalls. If there was any way to use the same PC at both sites, you'd be well on your way to finding an answer.
When I try to access a news site, I am getting a 451 error saying the content is not available. I can access this same news site from work, I am only getting this message when I'm at home.
This makes me think some setting is wrong either on my home network or my laptop - what do I check? I can access other news sites.
I am located in western NY, and the news site is in the Seattle (WA) area. All the references I found referred to the government blocking websites, but that isn't consistent with being able to reach it from one location but not another.