Most likely it will. They may or may not need some patches applied, but odds are they'll work just fine.
If in doubt, use Google. Type in the name of the game and something like "vista 64-bit" and see what comes up.
I am in the market for a new gaming computer and I am unsure if the 64-bit version of Vista would be able to run my older PC games such as Call of Duty, Jedi Academy, and Battlefield 2. Thanks!

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GameSpot
Giant Bomb
TechRepublic