Hi, Brett; You'll need to access the door lock actuator on the driver's door by removing the door panel. With test light, see if you are getting power when the door lock button is pushed. If so, replace the actuator. Same with the master switch on the driver's door. If the master switch is bad, it can affect the individual door switches. We've also discovered broken wires in the main harness that comes thru to the driver's door. (it is constantly being worn every time you use the driver's door. We've also run into more than one switch being faulty. Usually, one will go bad and won't be noticed until another one goes bad......Same with headlights. One can be out and not noticed until the other one goes.
Loren