If you can't clean them, even in Safe Mode, by far the best path to take is a clean install of the OS. Start all over, so to say.
They got me beat man! The bugs came, I killed them, so I thought. Now in the lower right hand corner, "Virus Alert", an "Antimalware Guard" program starts scanning upon startup, (I don't have this program, nor am I on the Internet at this point, I click "start", my "All Programs", "run" thru "my documents" choices gone, even my "log off". They took 'em all. My "turn off" computer only remains. My spyware doctor runs but gets kicked off after 25% done and the computer restarts again. Help, please. Running Win XP home edition, Dell Optiplex