It probably wouldn't work, but that's not the point.
As we were just saying, this guitar thing is getting out of hand. It's one thing for companies to go nuts trying to capitalize on the craze, but some fans are going even further on their own.
Case in point: One overly enthused gamer has come up with a conceptual combo of Guitar Hero and Nintendo's DS Lite. As SlashGear points out, the dimensions of a real guitar controller would make such a product difficult to impossible, but that's not the point. The issue is one of overload, people. When we said, "Get a grip," this isn't what we meant.