He will, however, give tomorrow's Macworld keynote address via satellite from the West Coast.
"[Jobs] has a personal scheduling conflict requiring him to be on the West Coast at this time," a spokesperson said, declining to elaborate. Added another: "It must be something he cares deeply about not to be in New York."
According to one Wall Street analyst, he is missing the trade show because his wife is expecting a baby.
Jobs is credited with helping to turn around the computer maker.
The interim CEO's keynote is expected to focus on the newest addition to Apple's lineup, the iMac desktop computer, as well as the consumer market, an Apple mainstay. The iMac already has been shown to users groups and at an educational trade show in San Diego.
"Steve grew up in the apricot orchards which later became known as Silicon Valley, and still lives there with his wife and three children," his biography notes.