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Botnet was responsible for 18 billion spam messages a day -- about 18 percent of the world's spam -- experts tell The New York Times.
The pair, who are linked to a malware network that stole more than $100 million, are already in custody in the U.K.
The company has said that thousands of bots are no longer receiving commands and attributed it to earlier legal action.
With a restraining order in hand, Microsoft is working to take down the spambot, which has infected hundreds of thousands of PCs worldwide.
Microsoft and its allies seized control servers Friday in two states as part of an operation to not just stop the botnets but also to disrupt how criminals use them.
Provider of free domains has agreed to delete or to transfer to Microsoft all subdomains the software giant had said were tied to the Kelihos botnet.
A Czech resident is accused of operating a botnet that infected tens of thousands of computers, serving spam and harvesting data. This is the third botnet Microsoft has taken down using the same legal and technical measures.
After winning a summary judgment against the perpetrators of the massive spamming network, the software giant hands evidence to federal law enforcement, including clues about the alleged ringleader.
Researcher warns people to be cautious about clicking on links related to Independence Day videos in e-mails over the holiday.
The software giant is on the verge of getting a court to grant it ownership over domains used in the Waledac spam botnet.