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Games, music, NPR, and more, all free for the download. Mancala FS5, NPR Mobile, Slacker Radio, Sportacular, Stanza, and Topple are suitable for the iPod Touch too.
Jason Rohrer's A Game for Someone is meant to be played in the distant future. But you could be the first to play it if you can dig it up in Nevada.
Game Center makes its debut on Macs via OS X 10.8, but until universal apps become commonplace, its use is limited.
Just because you're alone doesn't mean you have to play by yourself. These terrific games let you challenge other Internet-connected players.
For a board game geek, the iPhone and iPod Touch are fast becoming the best ways to shrink down a lot of cardboard and plastic pieces.