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If you need to search for files in OS X, one option it is to use the OS X Terminal application and some of its services.
A quick adjustment of the timeout values for key processes can greatly speed up otherwise laggy shutdowns in OS X.
New malware for OS X is making the rounds in security circles, called "Pintsized," but has not yet been determined to be much of a threat.
If your organization uses Citrix services, then the background programs for this service may be a cause for some slowdowns.
A new malware for OS X also acts as a reminder to monitor the launch services in OS X as a security precaution.
Tackling third-party launch agents and daemons may help odd system pauses after an OS update.
Disabling and re-enabling Spotlight indexing of the drive may help.
In OS X Mountain Lion, Apple has removed the option for personal Web sharing; however, this feature can be enabled if needed.
Adobe's new updating process should keep Mac users running the latest version of Adobe's popular Web plug-in.
While malware scanners can detect threats once definitions for them are available, you can monitor or lock your systems' launch agents folders to more proactively prevent attacks on your system.