If ColorSync Utility finds problems with profiles that it cannot fix, you may be able to address them by running the utility in root mode.
If your ColorSync profiles are not sticking in OS X, then a corrupt colorsync cache may be to blame.
While not a commonly recognized image editor, ColorSync Utility in OS X has some convenient editing options, such as quickly assigning color profiles to images.
Mac OS X 10.4.1: Distorted prints from Preview.app caused by ColorSync changes
Odds & Ends: ColorSync and scanners; Font Reserve bug
Odds & Ends: Mounting FireWire drives; AppleSher IP fixes; ColorSync help
Agfa ScanWise and ColorSync 2.6: a follow-up
New from Apple: ColorSync Profile First Aid; LocalTalk Bridge
ColorSync 2.6: possible problems
Epson Stylus Color 800 driver update: ColorSync and A4 paper size issues