You'll need to run the optical audio cable from your source to the box, which may result in some headaches. For one, you'll need to access the rear of your devices, which isn't always easy to do. Also, you'll need to either be close enough to said devices or acquire a long enough optical cable to reach where you'll be playing or watching. The included 3-foot optical audio cable really won't help you out here, so you're probably going to want to go out and find a wire at least double that length, depending on your situation.
In terms of sound quality, we were very impressed with the overall performance of the AX 720. We played various games on all consoles including Gears of War 2 on Xbox 360, Resistance 2 on PlayStation 3, and Shadow of the Colossus on PlayStation 2, and the AX 720 was really sharp and precise. During the height of some gun-fighting sequences, you're really immersed in the experience, something even a great 5.1 home theater system isn't always able to do. The headphones' excellent noise canceling and sound isolation really allow for this type of intimate effect to shine. Our only letdown was bass presence, as we didn't really feel the oomph associated with some low-frequency effects.
The included boom microphone can be detached when not in use and will work with Xbox 360, PlayStation 3, and PC gaming. When using it with PlayStation 3, you'll also need to attach an included USB cable from the white amp box to either device. You may need to invest in a longer cable, because the include 3-footer doesn't quite cut it. During our gaming sessions, we were heard clearly by our teammates. You can also adjust the microphone volume to your preference.
Overall, we really enjoyed the performance of the Tritton AX 720 gaming headset. Setting up the device is mostly easy and the experience the headphones create is very unique. Priced around $130 online, the Tritton AX 720 should be the only headphones you need for a while, considering the vast amount of sources it can support. Future game consoles should be able to work with it in terms of audio, but there may be issues with getting the headset feature to perform correctly.