Sideswiper

The main interface lets you swipe left and right among your different columns.
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Open the drawer

The sidebar on the left side of the screen houses basic navigation tools lists.
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Inline previews

The Plume timeline shows inline previews of tweeted photos and videos.
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What's trending

Plume lets you check out trending topics from around the globe or from any of nine different cities. The downside? It only lets you check out trends from nine different cities.
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Compose a tweet

Plume offers some basic tools for composing tweets. Autocomplete for usernames and the URL shortener are nice touches. Unfortunately, there's no geotagging option.
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Mute

Plume offers a few different muting options in case your timeline gets inundated with content that you don't care about.
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Custom columns

With Plume you can create custom columns so you can easily swipe among content from different Twitter accounts and even Facebook accounts.
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Take a look at yourself

From the sidebar on the left, you can access your profile and even edit your bio, location, and photo.
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