Though it's been several years, not much has changed in the update from the 5D to the 5D Mark II.
Like all Canon dSLRs, the 5D Mark II uses mostly electronic direct-access controls. Though I tend to prefer systems with more dedicated controls--most notably, the metering switches used by Nikon and the Sony Alpha DSLR-A900--Canon's operational metaphor still makes for relatively fluid shooting.
Canon's new Creative Auto mode--a semimanual mode with capabilities you can consider an advanced Auto mode or dumbed-down Program mode, depending upon your viewpoint--seems out of place on a camera in the 5D Mark II's class. But at least Canon didn't jettison a custom setting slot to make room for it as on the 50D.
The best part of Canon's dSLR designs are the the tried-and-true navigational controls, primarily the large thumbwheel and 8-way joystick. The new dedicated display toggle button (top left) is essential for switching into Live View and Movie capture mode.