Canon made several changes to increase consistency between shooting in vertical and horizontal orientations. On the front, there are two sets of user-assignable buttons, one pair positioned for horizontal and one pair for vertical-grip shooting.
There are a bunch of notable aspects to the new control layout. First, there's a dedicated Live View button. Now, the controls and readout on the left side of the body are for playback operations, while the right side has the active shooting controls. Some of the buttons as well as the multi controller are duplicated for better use with the vertical grip. And the inner ring of the control dial can be used to adjust settings while in video mode for quiet operation, while the new (to the pro bodies) Q button provides an interactive control panel that users of Canon's more mainstream are used to. The LCD is bigger as well.