Some users have experienced an issue in which iTunes 8.0.2 will not open. When users try to launch the application it quits and gives an "unknown error".
Apple Discussions poster ChkRazr writes:
"[My mac crashed and] I needed to hold down the "Power" key, which I did. Upon restarting, however, the Mac seems to be running okay but now my iTunes application refuses to load and I get the following error message: The iTunes application could not be opened. An unknown error occurred (13010)."
This problem has affected users who have crashed with a kernel panic (where the screen dims and displays white text explaining the computer needs to be restarted), but it has also happened for users who have updated iTunes. When applications crash or if the system freezes in the middle of an operation, it is possible for essential files to beoe corrupt. iTunes 8 contains support files for the "Genius" feature, which seems to be the root of this problems, and users have been able to successfully launch iTunes by first removing the Genius database.
Fix: Remove the Genius database In the "Finder" go to the /username/Music/iTunes/ directory and delete the "iTunes Library Genius.itdb" file. This should allow the program to launch again. This file will be recreated upon first use of the "Genius" feature.