Since most registry cleaners/optimizers tend to cause more troubles than they help, (just take a look at the problems members of these forums have experienced), UNTIL you can personally determine that all of the items identified by the registry cleaner to be "bad", so you can verify the correct things are being removed, then I'll suggest not using such.. I've also done a few tests of my own and seen NO performance improvement by using them.. I also find it interesting that many find a problem entry, say they've removed it, then find it again, and again.. In addition, since I've yet to find a registry cleaner review site which is unbiased, and can give ratings on the best vs the worst, I've decided not to use ANY of them.
Hope this helps.
I am using MacAfee, a malware program and a pc cleaner. But continue to have issues with speed and all of my programs running slow and locking up. I am pretty sure it is a registery problem and the programs that try to run every time I login.