If it gets riled up again, quit that app and see if it calms down again.
Check that you have the latest version of that app.
I've only had this drive for a few weeks, but I've noticed a tendency for the thing to always be running even when there's nothing for it to do. The head will click and gronk around continuously, the status light cycling over and over again. This generates a fair amount of heat in the drive after a while, and I imagine it'll wear down a lot faster if this keeps up.
I've tried several different approaches to solve this, including many wipes and reloads. At its worst, the drive would grind away even if the computer was asleep or the drive disconnected from the computer. A few times this happened immediately following a reformat on a supposedly "erased" (but not zeroed) disk. Nothing seemed to solve it.
Western Digital recommended that I try plugging it into a different outlet, which I did. This has calmed it down somewhat, but the problem mostly persists, and I continue to get frequent "drive in use" errors when I attempt to eject the disk, even though ? as far as I can tell ?