Did you try Grif's suggestion at link?
My answer is based solely on the clues you provided. If there were more clues, my answer may change.
My problem is this, i have IOBIT's advance systemcare with anti-virus and also Malwarebytes.
For some reason i can't open them i this messge -
C:\program files (x86) \iobit\advancedsystemcare with antivirus 2013\ASC.exe
The requested file is in use.
The same happens with Mawarebytes, i've tried uninstalling them and reinstalling them, neither does the trick... it feels they are locked in and i can't get at them. has anyone else had this problem?