I don't know of any good, free, Vista-compatible ISO editors off the top, but what does pop to mind is using a compression utility such as ExtractNow to extract the contents, modify them as needed, then use the ISO compilation feature of CDBurnerXP or the like to create a new ISO from the modified files. Performs the same basic duties with minimal extra work.
Hope this helps,
What is a good free ISO editor for Vista? I use InfraRecorder for burning CD's and DVD's. I also have Roxio My DVD avalibal if needed. Thease are both burning software not editors. I would like a free ISO editing software package.