They might be helpful if troubleshooting a setup problem but aren't, to my knowledge, necessary to for the OS to function. What I'd do would be move them to the recycle bin. Run the machine normally and empty the recycle bin the next time you do a cleanup. The disk cleanup utility tends to list expendable files quite conservatively. There are many more you can manually remove.
In Disk Cleanup today, I noticed there are 6,029KB in Setup Log Files, defined as "Files created by Windows". I didn't delete them, as I'm not clear what they are. Last Thursday, I uninstalled one printer; and today, I installed a different printer. Are these files most likely from that? Is it okay to delete them?