First, try restarting into Safe Mode again and run full system scans with BOTH of the antispyware tools you mentioned.
Next, please click on the link below and follow the cleanup steps below to eliminate unneeded startup programs and services, plus do a general cleanup of the machine.. (The first part of the page mentions installing and scanning with antispyware tools, but since you will have already done that, you can skip the first part.)
Cleanup Things To Do
Hope this helps and let us know how it goes.
I don't know my configuration, but I have a Compaq Presario, and Windows XP Home Edition operating system. I had to restart my computer in safe mode twice before it would load up properly. And every time I try to open my AVG 7.5 anti-virus program to run a virus scan, my computer freezes. This also happens when I try to open my Ad-Aware SE Personal spyware program. My mouse won't move, and even ctrl-alt-delete won't work! Can someone help me, as I have no clue what to do next!