I have been using it on my Desktop with dual monitors, neither of which are touch screen.
I'm using the older Beta testing Win 8 Consumer Preview, (not yet upgraded to the next tester version), and it works fine on a Desktop. It will also work on a laptop that isn't touch screen.
Windows 8 is the first OS, (I believe), to attempt to span all devices like Desktop/Laptop, through tablets/netbooks, to mobile smart phone technology. So the Metro user interface, (the name apparently recently dropped by MS), which is what users first see when Win 8 boots up, takes on different aspects depending what device it is installed on.
There is no user intervention required, Win 8 understands what device it is installed on whether touch screen or not, and adapts accordingly.
I hope that helps.
Have a desktop with windows Vista and a flat panel monitor that is not touch operated. Will I have to upgrade the monitor to use Windows 8?