What you may eventually find out is that the best will not get it all or deal with specific threats (ie CoolWeb.) What I find is a Suite of top tools is needed that I list at http://reviews.cnet.com/5208-6132-0.html?forumID=32&threadID=1313&messageID=15002
If that doesn't get it, then we move up to HIJACKTHIS and HJT Forums to help kick out that stubborn pest.
As of today, what free spyware detector/remover utility is now ranked as best? The last time I checked, the MS AntiSpyware-beta was at the top of the charts.