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A new way to predict breast cancer survival

A researcher who used to work in digital television has just led a team of Columbia University engineers to win the Sage Bionetworks / DREAM Breast Cancer Prognosis Challenge.

Dimitris Anastassiou, who is now a systems biologist (meaning he investigates interactions within biological systems), reports in the April 17 issue of Science Translational Medicine that his team's winning computation model is extremely predictive of breast cancer survival.

Before the challenge, Anastassiou and his team identified what they call "attractor metagenes," which are genetic signatures expressed in almost the exact same way across many types of cancer. Their new … Read more

How to edit an e-mail signature on BlackBerry 10

One of the first things I do after setting up a new device is to change the default e-mail signature. The default signature on new devices is usually a free advertisement for your carrier, device manufacturer, or both.

The default signature on a BlackBerry 10 device is "Sent from my BlackBerry 10 smartphone."

See what I mean? Free advertising.

Shortly after setting up my Z10 I sought out to change the e-mail signature. I looked in the Accounts section of the Settings app to no avail. I dug through other sections in the Settings app, even went into … Read more

The 404 1,224: Where we get in bed with the Sleep Doctor (podcast)

Leaked from today's 404 episode:

- Let's talk about Modafinil, the sleep-aid "smart drug" that inspired the movie "Limitless."

- Daylight saving time may cost America $434 million from lost sleep.

- Study: Women more affected by sleep deprivation.

- Sleeping stoned, the debate rolls on.

- We didn't answer your question? Sorry, there's only so much time in an episode, but why not follow Dr. Breus on Twitter and ask him yourself?

- Check out more information on Dr. Breus's exclusive line of signature mattresses on his Web site. Don't forget to sign up for his newsletter too!… Read more

A new high in high-end headphone amplifier design

The Fosgate Signature Headphone Amplifier is one of the very best-sounding amps I've ever used. It was designed by one of the greats, Jim Fosgate, a man who earned 18 audio related patents, founded a number of successful electronics companies -- oh, and he pioneered high-power car audio systems. He was also a big supporter of the very first home surround format -- quadraphonic -- in the early 1970s, and so committed to the format that even as quad was winding down, he designed the Fosgate Tate 101, arguably the finest quad processor of the era. Fosgate also created … Read more

How to extract Preview's signatures for use in other applications

The Preview application in OS X has an excellent option for capturing handwritten signatures and inserting them into PDF documents. This is great for signing forms, letters, and other items that require a signature. The process for doing so simply involves capturing a written signature with a Web cam, after which you can append them to any PDF document open in Preview.

Signatures that you associate with Preview in this manner are stored in an encrypted form, which is great for security but also means that Preview is the only program that can access them. Even though an inserted signature … Read more

Quickly sign any document with Preview

Legal forms, letters, and other documents are progressively migrating to digital media; however, the need for applying a signature to them is often still a requirement. While you can print these forms out, sign them and then fax, scan, or e-mail them after signing, another option is to apply a digitally saved version of your signature.

While one approach to doing this is to scan a document containing your signature and then crop it out and paste it in-line with your form, this requires that you keep the image of your signature readily available, and unless you have used transparencies, … Read more

How to set multiple e-mail signatures on iOS 6

Multiple e-mail signatures, a feature that should have been in iOS from day one, has finally been added to the operating system with the iOS 6 update.

Before iOS 6, users would have to set one generic signature and then add any extra information as they were sending the e-mail. Not anymore.

To set up your e-mail signatures, launch the Settings app and then select Mail, Contacts, Calendars. Scroll down until you find the Signature option and tap on it. You'll be presented with the option to set one e-mail address for all accounts, or to set a signature … Read more

The elusive paperless office: HelloSign says it has the answer

HelloFax CEO Jospeh Walla wants to kill printers and scanners -- doing away with them one digital signature at a time.

HelloFax is known for letting people send and receive faxes, request signatures, and fill out forms -- all without a physical document. From that service, the company is launching HelloSign, which lets people sign documents digitally.

Through HelloSign, Walla hopes to accomplish what many companies have tried and failed to do: create a paperless office. It was a dream born in the dot-com era but never realized, as workers still cling to physical paper despite the financial and environmental … Read more

Cannot access secured Web sites after OS X update

After updating OS X, some users have found they cannot access Web sites or other online content that is secured with a signed certificate. If you are experiencing this problem, when accessing such resources either through Safari or thorough applications like the Mac App Store, you may get an error stating that the Web site's identity cannot be verified, or that the certificate authority is an invalid issuer.

This problem is affecting a number of people who updated their systems from OS X 10.7.3 to the latest OS X 10.7.4 version. For some, it seems … Read more

HTC One S and crazy-expensive headphones are the top-reviewed tech this week

Sometimes, you really do get what you pay for. In this week's roundup of CNET's top-rated gear, I'll explore some premium choices, but prepare yourself for sticker rage.

HTC One S shows T-Mobile customers how the other half lives Case in point: On T-Mobile, cheaper phone plans mean fewer high-end smartphone choices -- and by fewer, we mean no Android Ice Cream Sandwich smartphones at all...until now. This week, T-Mo joined the ICS club with the HTC One S, which our reviewer Brian Bennett calls T-Mobile's best phone yet. It's thinner than the iPhone 4SRead more